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Scientist II, Pharmaceutical Sciences

Lawrence, KS Research & Pre-Clinical Development - Research Full Time
Company Summary:
Deciphera Pharmaceuticals is a pre-commercial stage biopharmaceutical company focused on improving the lives of cancer patients by addressing key mechanisms of drug resistance that limit the rate and/or durability of response to existing cancer therapies. Our small molecule drug candidates are directed against an important family of enzymes called kinases, known to be directly involved in the growth and spread of many cancers. We use our deep understanding of kinase biology together with a proprietary chemistry library to purposefully design compounds that maintain kinases in a “switched off” or inactivated conformation. These investigational therapies comprise tumor-targeted agents designed to address therapeutic resistance causing mutations and immuno-targeted agents designed to control the activation of immunokinases that suppress critical immune system regulators, such as macrophages. We have used our platform to develop a diverse pipeline of tumor-targeted and immuno-targeted drug candidates designed to improve outcomes for patients with cancer by improving the quality, rate and/or durability of their responses to treatment. 

We offer an outstanding culture and opportunity for personal and professional growth based on these key principles:
·       providing a collaborative, energized and fun work environment where people are empowered and supported in the achievement of their career goals
·       a diverse and multi-disciplinary workforce
·       dedicated and talented people who are passionate about achieving excellence in all they do
·       a work environment that allows you to balance your priorities
·       above all else, a commitment to the patients we serve

The Scientist II, Pharmaceutical Sciences, will support oncology drug discovery and development programs while collaborating closely with the chemistry and biology teams. We are seeking a highly motivated and energetic person to help conduct and analyze in vitro ADME assays. This position will report to the Head of Pharmaceutical Sciences and be located in our state-of-the-art research facility near the University of Kansas in Lawrence, Kansas.
 
Key Responsibilities
  • Conduct in vitro ADME assays for small molecules such as metabolic stability, CYP inhibition, and plasma protein binding
  • Perform sample preparation and LC-MS/MS-based quantitative analysis in biological matrices to support studies with drug discovery and development candidates
  • Effectively work in a team environment
  • Adhere to corporate policies including safety, FDA compliance and regulatory matters
  • Generate reports and presentations as required by the organization
  • Track and record data into corporate database
  • Additional tasks as needed to meet team goals
  • Required Qualifications
  • BS or MS in chemistry, biology, or in a related discipline with 4-6 years of relevant laboratory experience
  • Computer skills with MS Office (Excel, Word, PPT)
  • Flexibly contribute to team goals in a fast-paced and dynamic environment
  • Excellent interpersonal skills with strong oral and written communication skills
  • Preferred Qualifications
  • Experience and knowledge in LC-MS/MS-based bioanalysis
  • Hands-on experience in mammalian cell culture
  • Experience in data analysis using GraphPad Prism